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FLASH GENE

Symbol

RPS25

contributors: npt/mct - updated : 02-01-2023

HGNC name	ribosomal protein S25
HGNC id	10413

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

RiboP

HOMOLOGY

Homologene

FAMILY

ribosomal protein S25e family

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	structural constituent of ribosome
	having an essential role for proliferation in all cells (Robledo 2008)
	essential involvement of RPS25 for hijacking the ribosome
	at least two alternative translation initiation routes, internal ribosome entry site (IRES) initiation and ribosome shunting, rely on ribosomal protein S25 (RPS25)

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the small 40S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein	RPS25 interacted with MDM2 and inhibited its E3 ligase activity, resulting in the reduction of MDM2-mediated TP53 ubiquitination and the stabilization and activation of TP53
	RPS25-MDM2-TP53 regulatory feedback loop, which may have an important role in cancer development and progression
	in PSMD9 null cells, ribosomal proteins RPS25 and RPL15 fail to localise in the nucleolus

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in recurrent pregnancy loss

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   potential therapeutic target for C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia

ANIMAL & CELL MODELS