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FLASH GENE

Symbol

OGDHL

contributors: mct - updated : 04-01-2022

HGNC name	oxoglutarate dehydrogenase-like
HGNC id	25590

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	NDDEDV neurodevelopmental delay, epilepsy, deafness, visual defect
Location	10q11.23      Physical location : 50.942.687 - 50.970.425
Synonym name	alpha-ketoglutarate dehydrogenase, E1k subunit-like sequence
	2-oxoglutarate dehydrogenase E1 component precursor homolog
	alpha-ketoglutarate dehydrogenase-like
	oxoglutarate dehydrogenase like
Synonym symbol(s)	KGDE1KL, FLJ10851, KIAA1290
EC.number	1.2.4.2

DNA

TYPE	functioning gene
STRUCTURE	27.74 kb     23 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001143997 21 - 3330 NP_001137469 - 801 - 2021 34800363 NM_001143996 22 - 3535 NP_001137468 - 953 - 2021 34800363 NM_018245 23 - 3706 NP_060715 114.5 1010 - 2021 34800363 NM_001347822 21 - 3292 NP_001334751 - 801 - 2021 34800363 NM_001347820 22 - 3497 NP_001334749 - 953 - 2021 34800363 NM_001347826 20 - 3397 NP_001334755 - 611 - 2021 34800363 NM_001347823 22 - 3488 NP_001334752 - 950 - 2021 34800363 NM_001347825 22 - 3837 NP_001334754 - 741 - 2021 34800363 NM_001347824 22 - 3526 NP_001334753 - 950 - 2021 34800363 NM_001347821 23 - 4017 NP_001334750 - 801 - 2021 34800363 NM_001347819 23 - 3652 NP_001334748 - 1010 - 2021 34800363

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila CG11661
	homolog to C.elegans T22B11.5

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
text	mitochondrial localization

basic FUNCTION	converting alpha-ketoglutarate to succinyl coenzyme A in the Krebs cycle
	may thus participate in brain-specific control of 2-oxoglutarate distribution between energy production and synthesis of the neurotransmitter glutamate
	is an important anti-proliferative gene in cervical cancer
	OGDH and OGDHL play an essential part in a rate-limiting enzymatic reaction for the conversion of alpha-ketoglutarate (alpha-KG) to succinyl-CoA
	potential involvement of OGDHL in brain development and function
	both OGDHL and OGDH are required for mitochondrial metabolism in human neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid , carbohydrate , organic acid

signaling

Krebs cycle

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NDDEDV

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   contributed to hepatocellular carcinoma (HCC) development and survival by regulating glutamine metabolic pathways tumoral       loss of function can contribute to cervical tumorigenesis via activation of the AKT1 signaling pathway

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a promising prognostic biomarker for HCC
Therapy target
	System Type Disorder Pubmed cancer digestive liver therapeutic target for HCC neurology neurodegenerative alzheimer may be a potential strategy for AD treatment

ANIMAL & CELL MODELS