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FLASH GENE
Symbol OGDHL contributors: mct - updated : 15-06-2011
HGNC name oxoglutarate dehydrogenase-like
HGNC id 25590
Location 10q11.23      Physical location : 50.942.687 - 50.970.425
Synonym name
  • alpha-ketoglutarate dehydrogenase, E1k subunit-like sequence
  • 2-oxoglutarate dehydrogenase E1 component precursor homolog
  • Synonym symbol(s) KGDE1KL, FLJ10851, KIAA1290
    DNA
    TYPE functioning gene
    STRUCTURE 27.74 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3398 - 801 - 2008 18783430
    22 - 3603 - 953 - 2008 18783430
    23 - 3774 114.5 1010 - 2008 18783430
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG11661
    homolog to C.elegans T22B11.5
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text mitochondrial localization
    basic FUNCTION
  • converting alpha-ketoglutarate to succinyl coenzyme A in the Krebs cycle
  • may thus participate in brain-specific control of 2-oxoglutarate distribution between energy production and synthesis of the neurotransmitter glutamate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid , carbohydrate , organic acid
    signaling
    Krebs cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS