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FLASH GENE
Symbol ETV3 contributors: - updated : 27-12-2005
HGNC name ets variant gene 3
HGNC id 3492
Location 1q21-q23      Physical location : 157.094.458 - 157.108.383
Synonym symbol(s) PE1, METS, PE-1
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines numerous cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
ETS DNA-binding domain, PEA3 group
HOMOLOGY
Homologene
FAMILY
  • transcription factor of the ETS family, PEA3 subgroup
  • divergent member of the winged helix-turn-helix superfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor contributing to growth arrest during terminal macrophage differentiation by repressing target genes involved in RAS-dependent proliferation
  • acting as regulator of macrophage differentiation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to sequences containing the consensus pentanucleotide 5'-CGGA(AT)-3'
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS