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FLASH GENE

Symbol

ETV3

contributors: - updated : 27-12-2005

HGNC name	ets variant gene 3
HGNC id	3492

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21-q23      Physical location : 157.094.458 - 157.108.383
Synonym symbol(s)	PE1, METS, PE-1

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines	numerous cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

ETS DNA-binding domain, PEA3 group

HOMOLOGY

Homologene

FAMILY	transcription factor of the ETS family, PEA3 subgroup
	divergent member of the winged helix-turn-helix superfamily

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcriptional repressor contributing to growth arrest during terminal macrophage differentiation by repressing target genes involved in RAS-dependent proliferation
	acting as regulator of macrophage differentiation

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to sequences containing the consensus pentanucleotide 5'-CGGA(AT)-3'

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS