protein
| direct binding to cytoskeletal protein actin (providing a novel mechanism for trafficking of not only AQP2 but also recycling channel proteins) |
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putative substrate of calcineurin phosphatase in the kidney |
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interacts with other players of the ESCRT machinery as well as with two known cargo proteins, AQP2 and EGFR, whose degradation is affected upon reduction of VTA1 expression |
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interacting with AVP (modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water) |
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intreracting with TBC1D4 (decreased expression of TBC1D4 is likely to play a role in the translocation of AQP2 to the plasma membrane) |
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CUL5 is involved in the regulation of AQP2 protein concentration and may play a role in regulating water balance |
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NR1H4 plays a critical role in the regulation of urine volume, and its activation increases urinary concentrating capacity mainly via up-regulating its target gene AQP2 expression in the collecting ducts |
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GATA2 regulates the AQP2 gene expression in collecting duct (CD) cells and contributes to the maintenance of the body water homeostasis |
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ELF5 is a principal cell lineage specific transcription factor in the kidney that contributes to AQP2 and AVPR2 gene expression |
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interaction between the renal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein VTA1 targets AQP2 to multivesicular bodies and facilitates lysosomal degradation |
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through direct interaction with AQP2, EZR facilitates AQP2 endocytosis, thus linking the dynamic actin cytoskeleton network with AQP2 trafficking |
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FXYD1 (phospholemman), better known as a regulator of Na,K-ATPase, has a role in AQP2 trafficking |