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FLASH GENE
Symbol GTF2F2 contributors: - updated : 26-06-2007
HGNC name general transcription factor IIF, polypeptide 2, 30kDa
HGNC id 4653
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal sequences including a DNA binding domain mediating initiation activity
  • sequences immediately upstream of the C terminus mediating elongation activity
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Y39b6a.1
    Homologene
    FAMILY
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • showing ATP-dependent DNA-helicase activity
  • POL2 recruitment to TF2B
  • increasing the average rate of RNA chain elongation across DNA templates
  • functionnng with GTF2F1 to establish stable preinitiation complexes
    • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of an alpha and a beta subunit
  • subunit of RNA polymerase II transcription initiation factor IIF
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein RNA plymerase II
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS