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FLASH GENE
Symbol GTF2F2 contributors: - updated : 26-06-2007
HGNC name general transcription factor IIF, polypeptide 2, 30kDa
HGNC id 4653
Location 13q14      Physical location : 45.694.630 - 45.858.237
Synonym name RNA polymerase associated protein, RAP30
Synonym symbol(s) RAP30, TF2F2, BTF4
DNA
TYPE functioning gene
STRUCTURE 163.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal sequences including a DNA binding domain mediating initiation activity
  • sequences immediately upstream of the C terminus mediating elongation activity
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Y39b6a.1
    Homologene
    FAMILY
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • showing ATP-dependent DNA-helicase activity
  • POL2 recruitment to TF2B
  • increasing the average rate of RNA chain elongation across DNA templates
  • functionnng with GTF2F1 to establish stable preinitiation complexes
    • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of an alpha and a beta subunit
  • subunit of RNA polymerase II transcription initiation factor IIF
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein RNA plymerase II
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS