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FLASH GENE
Symbol UBA52 contributors: - updated : 27-12-2005
HGNC name ubiquitin A-52 residue ribosomal protein fusion product 1
HGNC id 12458
Location 19p13.1-p12      Physical location : 18.682.613 - 18.688.269
Synonym name ubiquitin and ribosomal protein L40 precursor
Synonym symbol(s) RPL40, HUBCEP52, CEP52
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • promoter located in a CpG-rich island
  • having SP1-binding sites
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • encoding a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus
  • zinc finger like domain
    • HOMOLOGY
    interspecies ortholog to murine Uba52
    homolog to Drosophila Ubi-p63E
    homolog to C.elegans ubq-2
    homolog to yeast S.cerevisiae Ubi1/Ubi2
    Homologene
    FAMILY L40E family of ribosomal proteins
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the ATP-dependent selective degradation of cellular proteins, the maintenance of chromatin structure, the regulation of gene expression, the stress response, and ribosome biogenesis
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component ribosomal subunit
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS