Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GRIN2A | contributors: mct - updated : 28-08-2016 |
HGNC name | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
HGNC id | 4585 |
|
Corresponding disease |
| ||
Location | 16p13.2 Physical location : 9.847.266 - 10.276.611 | ||
Synonym name | |||
| |||
| |||
Synonym symbol(s) | NR2A, NMDAR2A, LKS, EPND, FESD, GluN2A |
DNA |
TYPE | functioning gene |
STRUCTURE | 429.35 kb 14 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
motif | repetitive sequence |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
---|
text | variants 1 and 2 encode the same protein |
|
EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | fetal |
Text | brain |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
|
conjugated | GlycoP |
mono polymer | heteromer , dimer |
isoforms | Precursor |
HOMOLOGY |
interspecies | ortholog to murine Grin2a |
Homologene |
FAMILY | |
| |
|
CATEGORY | receptor membrane , transport channel |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | post-synaptic membrane |
CELLULAR PROCESS | cell life, cell death/apoptosis |
PHYSIOLOGICAL PROCESS | nervous system |
text | |
|
PATHWAY |
metabolism |
signaling | neurotransmission |
glutamate signaling pathway/excitatory neurotransmission |
a component | |
|
INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
cell & other |
REGULATION |
activated by | selectively activated by the artificial glutamate analog N-methyl D-aspartate |
Other | abundantly tyrosine-phosphorylated by the Src family kinases (Tyr 1292, Tyr 1325, and Tyr 1387 are reported to be major phosphorylation site) |
ASSOCIATED DISORDERS |
corresponding disease(s) | EPND |
Other morbid association(s) |
|
Susceptibility |
|
Variant & Polymorphism SNP , other | |
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |