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FLASH GENE

Symbol

GPX4

contributors: mct/npt/pgu - updated : 24-09-2019

HGNC name	glutathione peroxidase 4 (phospholipid hydroperoxidase)
HGNC id	4556

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HXALI , SMDS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in blood of women with preeclampsia constitutional     --low   significant reductions in expression of GPX1, GPX3, GPX4 in placentae from women with preeclampsia

Susceptibility

to sterility and infertility to cardiovascular autonomic neuropathy in individuals with type 1 diabetes to Preeclampsia (PE)

Variant & Polymorphism other	functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
	rs713041 in GPX4 may play a key role in the pathogenesis of PE

Candidate gene	is a possible candidate susceptibility gene for Kashin-Beck disease (KBD)
Marker	GPX4 and GPX7 are possible markers for improving Hepatocellular carcinoma (HCC) diagnosis/prognosis
	overexpression of GPX4 is an independent prognostic predictor in diffuse large B-cell lymphoma
Therapy target

ANIMAL & CELL MODELS

spermatozoa of mice lacking both the sperm nucleus glutathione peroxidase 4 (snGPx4) and the epididymal glutathione peroxidase 5 (GPx5) activities display sperm nucleus structural abnormalities including delayed and defective nuclear compaction, nuclear instability and DNA damage