SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| intracellular,nuclear envelope
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| text
| at least three isoforms in testis: cytosolic, mitochondrial and nuclear |
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nuclear form of GPX4 has a peculiar distribution in sperm head, being localized to nuclear matrix and acrosome  |
| basic FUNCTION
| glutathione peroxidase, free radical detoxification, catabolic pathway of activated oxygen species, oxydoreductase |
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catalyzing the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage |
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playing an indispensable role for structural integrity of spermatozoa and to codetermine sperm motility and viability |
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playing a pivotal role in brain development and function |
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multifunctional and it acts as a reducing enzyme of peroxidized phospholipids and thiols and as a structural protein |
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essential antioxidant enzyme having multiple functions |
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GPX5 protein, and the epithelial proteins GPX1, GPX3, and cellular GPX4, all functioning in the mammalian epididymis at different stages of the sperm epididymal journey, and in different epididymis compartments |
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nuclear form of GPX4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization |
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GPX4 is a critical antioxidant enzyme for the maturation and survival of photoreceptor cells |
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is essential for maintaining oxidative homeostasis and keeping defense against oxidative stress in conjunctival epithelial cells |
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antioxidant defense enzyme active in repairing oxidative damage to lipids, that is a key inhibitor of ferroptosis, a non-apoptotic form of cell death involving lipid reactive oxygen species |
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ferroptosis inhibition by GPX4 is essential for motor neuron health and survival |
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is an important antioxidant enzyme for maintaining redox status and protecting corneal endothelial cells from oxidative stress |
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is a monomeric glutathione peroxidase, unique in reducing the hydroperoxide group (-OOH) of fatty acids esterified in membrane phospholipids |
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paternal acetylated histones and acrosomal nuclear GPX4 are directly involved in fertilization |
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antioxidant enzyme, having biological important functions such as signaling cell death by suppressing peroxidation of membrane phospholipids |
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GPX4 regulates reactive oxygen species-induced cell death |
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ferroptosis is mediated by the accumulation of lipid peroxides upon the depletion/or inhibition of glutathione peroxidase 4 (GPX4) |
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unique antioxidant enzyme that can directly reduce phospholipid hydroperoxide |
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increased lipid peroxidation resulting from reduced GPX4 expression levels may be causally associated with lung fibrosis development |
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GPX1 and GPX4 dampen phosphorylation cascades predominantly via prevention of inactivation of phosphatases by H2O2 or lipid hydroperoxides |
