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FLASH GENE

Symbol

GPX2

contributors: mct - updated : 19-10-2022

HGNC name	glutathione peroxidase 2 (gastrointestinal)
HGNC id	4554

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.59 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	a unique responsive element was found in the promoter of the GPX2 gene that can be activated and bound by TP63 but not TP53

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002083 2 - 922 NP_002074 - 190 - 2022 35193955

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Homo sapiens   intestine         Homo sapiens   liver           stomach       highly Homo sapiens Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	glutathione peroxidase involved in free radical detoxification
	involved in transcriptional response to exogenous redox agents and catabolic pathway of activated oxygen species
	H2O2 neutralization by GPX2 is essential for maintaining clonogenic and metastatic capacity, but also for the generation of differentiated proliferating tumor mass
	GPX2 plays an important role in bladder carcinogenesis through the regulation of apoptosis against intracellular ROS
	GPX2 and GPX1 have overlapping functions in controlling inflammatory lipid mediator synthesis and, most probably, exert their anti-inflammatory effects by preventing excessive PGE2 production
	GPX2 regulates the balance between regeneration and apoptotic cell shedding in the intestine
	unique role for redox signaling by GPX2 dysregulation in breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	direct target of TP63, inhibiting oxidative stress-induced apoptosis in a TP53-dependent manner
	GPX2, TXNRD2 and TXNRD3 are regulated by WNT signalling in the intestinal epithelium

cell & other

REGULATION

activated by

TP63

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in Pancreatic cancer tissues tumoral     --over   contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be considered as a novel biomarker in bladder cancer
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas GPX2 silencing could inhibit the Wnt pathway, subsequently suppress PC development cancer urinary   therapeutic target in bladder cancer

ANIMAL & CELL MODELS