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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

DSC3

contributors: mct - updated : 11-04-2020

HGNC name	desmocollin 3
HGNC id	3037

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HTSV

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function is a common event in primary breast tumor specimens, and gene silencing in breast tumors is frequently linked to aberrant cytosine methylation and concomitant changes in chromatin structure tumoral     --other   de novo expression in colorectal cancer constitutional germinal mutation       in microphthalmia tumoral     --low   in colorectal cancer (CRC) tumoral     --low   DNA methylation contributes to down-regulation of DSC3 in prostate cancer, and loss of DSC3 predicts poor clinical outcome constitutional     --other   IgG autoantibodies against DSC3, induce loss of keratinocyte adhesion and thus may contribute to blister formation in pemphigus

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	in primary lung tumors, DSC3 was a potential diagnostic marker for lung squamous cell carcinoma, and DSC3 DNA hypermethylation was correlated with poor clinical outcome
Therapy target
	System Type Disorder Pubmed cancer digestive colon may serve as a novel therapeutic target for CRC

ANIMAL & CELL MODELS