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FLASH GENE
Symbol LCR-HB-B@ contributors: npt - updated : 29-04-2010
DNA
TYPE locus Control Region
text structure composed of six DNase I hypersensitive sites (HS), five located 5' of HB-NA@ and one 3' of the cluster, containing transcription factor binding sites (3 GATA1, 2 NFE2/AP1 and a GT/SP1)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • conferring high level and developmental tissue specific expression of beta globulin genes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by HS3 activated by KLF1 (EKLF) through chromatin remodeling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS