Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GYS2 contributors: mct - updated : 16-05-2009
HGNC name glycogen synthase 2 (liver)
HGNC id 4707
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
intraspecies paralog to GYS1
Homologene
FAMILY
  • mammalian/fungal glycogen synthase family
  • glycosyltransferase 3 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • the rate limiting enzyme of the insulin-induced glycogenesis, transferring glucose units from UDP-Glc to a glycogen primer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • complexing with GYG2 and TRIM7
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target gene of PPARalpha (PPARA), PPARbeta/delta and PPARgamma (PPARG) (Mandard (2007)
    • cell & other
    REGULATION
    activated by stimulated (dephosphorylated) by insulin
    inhibited by phosphorylated by epinephrine or glucagon
    Other regulated by CLOCK (regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of GYS2)
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD0
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS