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FLASH GENE

Symbol

GYS2

contributors: mct - updated : 16-05-2009

HGNC name	glycogen synthase 2 (liver)
HGNC id	4707

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	GSD0 glycogen storage disease, type 0
Location	12p12.1      Physical location : 21.689.124 - 21.757.781
Synonym name	glycogen (starch) synthase, liver
Synonym symbol(s)	GYSL
EC.number	2.4.1.11

DNA

TYPE	functioning gene
STRUCTURE	68.66 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021957 16 - 3132 NP_068776 80.9 703 - 1994 8188280

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

intraspecies

paralog to GYS1

Homologene

FAMILY	mammalian/fungal glycogen synthase family
	glycosyltransferase 3 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

the rate limiting enzyme of the insulin-induced glycogenesis, transferring glucose units from UDP-Glc to a glycogen primer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

complexing with GYG2 and TRIM7

INTERACTION

DNA

RNA

small molecule

protein

direct target gene of PPARalpha (PPARA), PPARbeta/delta and PPARgamma (PPARG) (Mandard (2007)

cell & other

REGULATION

activated by

stimulated (dephosphorylated) by insulin

inhibited by

phosphorylated by epinephrine or glucagon

Other

regulated by CLOCK (regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of GYS2)

ASSOCIATED DISORDERS

corresponding disease(s)

GSD0

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS