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FLASH GENE
Symbol RAP1GAP contributors: mct/shn - updated : 12-07-2012
HGNC name RAP1 GTPase activating protein
HGNC id 9858
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GOLOCO domain
  • a rap-gap domain
  • a catalytic domain from amino acids 75 to 416
    • HOMOLOGY
    interspecies ortholog to Rap1GAP, Mus musculus
    ortholog to Rap1GAP, Rattus norvegicus
    ortholog to rap1gap, Danio rerio
    ortholog to RAP1GAP, Pan troglodytes
    Homologene
    FAMILY
  • GTP binding protein family
    • CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • provides a catalytic asparagine to stimulate GTP hydrolysis
  • GTPase activator for the nuclear ras-related regulatory protein RAP1A (krev-1), converting it to the putatively inactive GDP-bound state
  • putative tumor suppressor gene in pancreatic cancer
  • involved in the signal transduction of myelin-associated glycoprotein (MAG)
  • implicated as a putative tumor/invasion suppressor in the thyroid (Tsygankova 2007)
  • functions by switching off RAP1, the Ras-like protein that has been associated with carcinogenesis (Mitra 2008)
  • inhibits tumor growth but induces MMP2- and MMP9-mediated squamous cell carcinoma (SCC) invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs (Mitra 2008)
  • important regulator of retinal pigment epithelial cell junctions, and required for maintenance of barrier function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • regulates integrin-mediated cell adhesion
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-subunits of the G(i) family of heterotrimeric G-protein
  • Galpha(z)
  • target of oncogenic Ras (Tsygankova 2007)
  • RET and suppresses GDNF-induced neurite outgrowth
  • MEX3B regulate the cortical level of activated RAP1A, a small G protein controlling phagocytosis and cell-cell interaction, through the activation and transport of RAP1GAP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in pancreatic cancer, in progression
    tumoral     --low  
    in papillary thyroid carcinomas (Nellore 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Knockdown of Rap1 or inhibition of its activity in retinal pigment epithelium reduces Transepithelial electrical resistance and electrical impedance of the retinal pigment epithelial monolayers