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FLASH GENE
Symbol RAP1GAP contributors: mct/shn - updated : 12-07-2012
HGNC name RAP1 GTPase activating protein
HGNC id 9858
DNA
TYPE functioning gene
STRUCTURE 73.15 kb     27 Exon(s)
MAPPING cloned Y linked N status confirmed
Map pter - D1S3720 - D1S334 - RAP1GAP - D1S2725 - D1S2702 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 3334 73.2 663 - Weiss (1994)
27 - 3495 75.06 681 - Weiss (1994)
25 - 3301 80.5 727 - Weiss (1994)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
 thyroid   highly
Nervousbrainforebraincerebral cortex highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GOLOCO domain
  • a rap-gap domain
  • a catalytic domain from amino acids 75 to 416
    • HOMOLOGY
    interspecies ortholog to Rap1GAP, Mus musculus
    ortholog to Rap1GAP, Rattus norvegicus
    ortholog to rap1gap, Danio rerio
    ortholog to RAP1GAP, Pan troglodytes
    Homologene
    FAMILY
  • GTP binding protein family
    • CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • provides a catalytic asparagine to stimulate GTP hydrolysis
  • GTPase activator for the nuclear ras-related regulatory protein RAP1A (krev-1), converting it to the putatively inactive GDP-bound state
  • putative tumor suppressor gene in pancreatic cancer
  • involved in the signal transduction of myelin-associated glycoprotein (MAG)
  • implicated as a putative tumor/invasion suppressor in the thyroid (Tsygankova 2007)
  • functions by switching off RAP1, the Ras-like protein that has been associated with carcinogenesis (Mitra 2008)
  • inhibits tumor growth but induces MMP2- and MMP9-mediated squamous cell carcinoma (SCC) invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs (Mitra 2008)
  • important regulator of retinal pigment epithelial cell junctions, and required for maintenance of barrier function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • regulates integrin-mediated cell adhesion
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-subunits of the G(i) family of heterotrimeric G-protein
  • Galpha(z)
  • target of oncogenic Ras (Tsygankova 2007)
  • RET and suppresses GDNF-induced neurite outgrowth
  • MEX3B regulate the cortical level of activated RAP1A, a small G protein controlling phagocytosis and cell-cell interaction, through the activation and transport of RAP1GAP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in pancreatic cancer, in progression
    tumoral     --low  
    in papillary thyroid carcinomas (Nellore 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Knockdown of Rap1 or inhibition of its activity in retinal pigment epithelium reduces Transepithelial electrical resistance and electrical impedance of the retinal pigment epithelial monolayers