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FLASH GENE

Symbol

CREM

contributors: mct - updated : 19-02-2018

HGNC name	cAMP responsive element modulator
HGNC id	2352

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   down-regulated in the majority of chilhood leukemias constitutional     --over   in T cells from patients with systemic lupus erythematosus (SLE)

Susceptibility

panic disorder

Variant & Polymorphism repeat	shorter promoter P2 trinucleotide polymorphism (minor role)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in Crem-/- mice, modulated expression of cholesterogenic genes