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FLASH GENE
Symbol PPP1CA contributors: mct/npt - updated : 10-07-2015
HGNC name protein phosphatase 1, catalytic subunit, alpha isoform
HGNC id 9281
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Ppp1ca
intraspecies homolog to PPP1CB
Homologene
FAMILY
  • PPP family of phosphatase
  • PP-1 subfamily
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine/threonine protein phosphatase 1, catalytic subunit, involved in mitotic exit
  • control of cell proliferation/regulation of
  • regulating glycogen metabolism, muscle contractility, protein synthesis, ionic conductances and long-term synaptic plasticity
  • regulates critical cellular events, such as cell cycle progression, and apoptosis
  • PPP1CA and PPP1CC are the primary phosphatases that are responsible for IFIH1 and DDX58 dephosphorylation
    • that lead to their activation
  • PPP1CA and PPP1CB - are capable of compensating the loss of PPP1CC in every tissue except in testis
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • catalytic subunit of protein phosphatase 1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mn2+
    • protein
  • P110RB (from mitosis to early G1)
  • directly interacted with TRIM28 under basal conditions
  • TP53BP2 facilitates the interaction between TAZ and PPP1CA to promote TAZ dephosphorylation
  • phosphatase activity of PPP1CA is required for PREX1 activation
  • PPP1CA stimulates PREX1-mediated RAC1-dependent changes in endothelial cell morphology
  • binds to PPP1CA and causes its retention in the cytosol which suggests that YWHAZ regulates nuclear trafficking of PPP1CA in mammalian cells
  • PARD3 promotes the interaction between PPP1CA and LATS1 to induce LATS1 dephosphorylation and inactivation, therefore leading to dephosphorylation and activation of TAZ
  • PPP1R15B functions with the PPP1CA phosphatase to maintain dephosphorylated EIF2S1 in unstressed cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in oral squamous cell carcinoma, in progression
    Susceptibility type I multiple endocrine neoplasia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS