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FLASH GENE
Symbol PPP1CA contributors: mct/npt - updated : 10-07-2015
HGNC name protein phosphatase 1, catalytic subunit, alpha isoform
HGNC id 9281
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Lymphoid/Immunethymus   highly
 tonsils   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Ppp1ca
intraspecies homolog to PPP1CB
Homologene
FAMILY
  • PPP family of phosphatase
  • PP-1 subfamily
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine/threonine protein phosphatase 1, catalytic subunit, involved in mitotic exit
  • control of cell proliferation/regulation of
  • regulating glycogen metabolism, muscle contractility, protein synthesis, ionic conductances and long-term synaptic plasticity
  • regulates critical cellular events, such as cell cycle progression, and apoptosis
  • PPP1CA and PPP1CC are the primary phosphatases that are responsible for IFIH1 and DDX58 dephosphorylation
    • that lead to their activation
  • PPP1CA and PPP1CB - are capable of compensating the loss of PPP1CC in every tissue except in testis
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • catalytic subunit of protein phosphatase 1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mn2+
    • protein
  • P110RB (from mitosis to early G1)
  • directly interacted with TRIM28 under basal conditions
  • TP53BP2 facilitates the interaction between TAZ and PPP1CA to promote TAZ dephosphorylation
  • phosphatase activity of PPP1CA is required for PREX1 activation
  • PPP1CA stimulates PREX1-mediated RAC1-dependent changes in endothelial cell morphology
  • binds to PPP1CA and causes its retention in the cytosol which suggests that YWHAZ regulates nuclear trafficking of PPP1CA in mammalian cells
  • PARD3 promotes the interaction between PPP1CA and LATS1 to induce LATS1 dephosphorylation and inactivation, therefore leading to dephosphorylation and activation of TAZ
  • PPP1R15B functions with the PPP1CA phosphatase to maintain dephosphorylated EIF2S1 in unstressed cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in oral squamous cell carcinoma, in progression
    Susceptibility type I multiple endocrine neoplasia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS