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FLASH GENE

Symbol

PPP1CA

contributors: mct/npt - updated : 10-07-2015

HGNC name	protein phosphatase 1, catalytic subunit, alpha isoform
HGNC id	9281

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed 1.alpha-1 - splicing - 35.4 311 - Durfee differing only in the N terminal region 1.alpha 2 - splicing 1488 37.5 330 - Durfee, Eto (2007) differing only in the N terminal region variant 2 - - 1356 - 286 - Eto (2007) variant 3 - - 1521 - 341 - Eto (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Lymphoid/Immune thymus       highly   tonsils       highly Reproductive female system uterus cervix   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Ppp1ca

intraspecies

homolog to PPP1CB

Homologene

FAMILY	PPP family of phosphatase
	PP-1 subfamily

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	serine/threonine protein phosphatase 1, catalytic subunit, involved in mitotic exit
	control of cell proliferation/regulation of
	regulating glycogen metabolism, muscle contractility, protein synthesis, ionic conductances and long-term synaptic plasticity
	regulates critical cellular events, such as cell cycle progression, and apoptosis
	PPP1CA and PPP1CC are the primary phosphatases that are responsible for IFIH1 and DDX58 dephosphorylation
	that lead to their activation
	PPP1CA and PPP1CB - are capable of compensating the loss of PPP1CC in every tissue except in testis

CELLULAR PROCESS	cell cycle, division, mitosis
	cell life, proliferation/growth
	protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

catalytic subunit of protein phosphatase 1

INTERACTION

DNA

RNA

small molecule	metal binding,
	Mn2+

protein	P110RB (from mitosis to early G1)
	directly interacted with TRIM28 under basal conditions
	TP53BP2 facilitates the interaction between TAZ and PPP1CA to promote TAZ dephosphorylation
	phosphatase activity of PPP1CA is required for PREX1 activation
	PPP1CA stimulates PREX1-mediated RAC1-dependent changes in endothelial cell morphology
	binds to PPP1CA and causes its retention in the cytosol which suggests that YWHAZ regulates nuclear trafficking of PPP1CA in mammalian cells
	PARD3 promotes the interaction between PPP1CA and LATS1 to induce LATS1 dephosphorylation and inactivation, therefore leading to dephosphorylation and activation of TAZ
	PPP1R15B functions with the PPP1CA phosphatase to maintain dephosphorylated EIF2S1 in unstressed cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in oral squamous cell carcinoma, in progression

Susceptibility

type I multiple endocrine neoplasia

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS