SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| text
| luminal space of the terminal cisternae of RE |
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sarcoplasmic reticulum |
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CASQ1, CASQ2 are present in the endoplasmic reticulum vacuolar domains of some neurons and smooth muscles  |
| basic FUNCTION
| calcium storage protein in terminal cisternae of sarcoplasmic reticulum |
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represents the Ca2+ reservoir of mitochondria, the function of which could be similar to what has been reported for calsequestrine in the sarcoplasmic reticulum (Bataille 1994) |
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is thought to play a dual role in excitation-contraction coupling: buffering free Ca(2+) increasing SR capacity, and modulating the activity of the Ca(2+) release channels (RyRs) (Paolini 2007) |
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high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle |
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involved in intracellular storage and release of calcium, a process that has been shown to mediate glucose transport in muscle |
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essential for the normal development of the sarcoplasmic reticulum (SR)and its calcium release units and for the storage and release of appropriate amounts of SR Ca(2+) (Paolini 2007) |
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curtails RYR1 opening in response to a single action potential to maintain Ca(2+) and allow repeated Ca(2+) release and graded activation with increased stimulation frequency (Wei 2009) |
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functions as both a Ca(2+)-binding protein and a luminal regulator of ryanodine receptor (RYR1)-mediated Ca(2+) release (Dainese (2009) |
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principal Ca(2+) storage protein of the sarcoplasmic reticulum of skeletal muscle |
