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FLASH GENE
Symbol HB-A@ contributors: - updated : 11-09-2006
Location 16p13.3      Physical location : -
Genatlas name hemoglobin, alpha cluster, 20-30 kb : 5'-HBZ, HBZP, HBM, HBAP1, HBA2, HBA1, HBQ1-3' (see symbols)
DNA
TYPE cluster
regulatory sequence Locus Control Region
text structure
  • three functional genes Hb2-HBA2-HbA1
  • three pseudogenes [HBZP-HBAP2-HBAP1] and the gene HbQ1(transcript only detected in erythro leukemia and erythro fetal cells)
  • locus control region LCRA confered high level developmental and tissue specific expression, fetal hemoglobin (alpha2 and gamma2) expressed in liver and adult hemoglobin (alpha2 and gamma2) in bone marrow
    • MAPPING cloned   linked Y status provisional
    Map pter - IL9RP3 - MPG - (LCR-HBA@ ,D16S262 ) - HBZ - HBZP - HBM - HBAP1 - HBA2 - HBA1 HBA1 - HBQ1 - ARHGDIG - PDIA2 - cen
    Authors Flint (97)
    Text see MPG
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS