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FLASH GENE

Symbol

HAGH

contributors: - updated : 03-03-2006

HGNC name	hydroxyacyl glutathione hydrolase
HGNC id	4805

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HAGH I1 - - 1519 28.8 260 - Cordell mitochondrial, 9 exons an additional 500-bp exon at the start of the sequence (termed exon A) HAGH I2 - - 1011 - - cytosolic Cordell 8 exons

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

metallo-beta-lactamase superfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic

basic FUNCTION

catalyzing the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

glyoxal pathway

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binding two Zn2+ per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in superficial or invasive bladder cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS