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FLASH GENE

Symbol

FGFBP1

contributors: mct - updated : 07-03-2012

HGNC name	fibroblast growth factor binding protein 1
HGNC id	19695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage
cell lines	squamous cell carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a heparin-binding domain (AAs 110-143)
	C-terminal fragment of FGFBP1 (AAs 193-234) was identified as the minimum binding domain for FGF

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	secreted

basic FUNCTION	protecting both FGF molecules from acid inactivation
	inhibiting the mitogenic activity of FGF1
	could influence cancer growth and tissue remodeling via its interaction with perlecan (HSPG2)
	its overexpression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair
	secreted carrier proteins that release fibroblast growth factors (FGFs) from the extracellular matrix storage and thus enhance FGF activity
	can be rate-limiting for tumor growth and serves as an angiogenic switch molecule
	involved in the process of epithelial repair
	can release FGFs from their local extracellular matrix storage, chaperone them to their cognate receptors, and thus modulate FGF signaling
	play a significant role in fine-tuning the complex FGF signaling network during distinct phases of embryonic development
	chaperone FGFs stored in the extracellular matrix to their receptor, and can thus modulate FGF signaling
	can enhance FGF effects that are required for the healing and repair of injured tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

part of KLF5-FGFBP1-pERK-DUSP1 signaling axis, that may provide new therapeutic targets for invasive breast cancer

INTERACTION

DNA

RNA

small molecule

protein	binding to FGF1 or FGF2 in a reversible manner
	binding to HSPG2
	interacts with FGF7, FGF10, and with the recently identified FGF22
	interacting with KLF5 (may promote breast cancer cell proliferation at least partially through directly activating the FGFBP1 mRNA transcription)
	FGFBP1 was a direct transcriptional target of SOX12

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair

Susceptibility

to osteoporosis

Variant & Polymorphism other	sequence variation in FGFBP1 may contribute to variation in BMD, possibly influencing osteoporosis risk

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     represents an increasingly promising target molecule in anti-tumor therapy

ANIMAL & CELL MODELS