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FLASH GENE

Symbol

CACNG8

contributors: mct - updated : 26-03-2008

HGNC name	calcium channel, voltage-dependent, gamma subunit 8
HGNC id	13628

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.4      Physical location : 54.466.293 - 54.486.139
Synonym name	neuronal voltage-gated calcium channel gamma-8 subunit
Synonym symbol(s)	CCG8

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	19.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - PRKCG - CACNG7 - CACNG8 - CACNG6 - qter
Authors	Burgess (01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 1417 - 425 - Chu (2001)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Cacng8

Homologene

FAMILY

PMP22/EMP/MP20 family, CACNG subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	distributed both in synaptic and extra-synaptic plasma membranes of the hippocampal neuron

basic FUNCTION	stabilizing the calcium channel in an inactive (closed) state
	initiate translation from a non-AUG (CUG) start codon
	have distinct roles in postsynaptic membranes under the regulation of different intracellular signaling pathways

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS