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FLASH GENE
Symbol POLR3K contributors: mct - updated : 31-01-2022
HGNC name polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
HGNC id 14121
Corresponding disease
HLD21 leukodystrophy, hypomyelinating, 21
Location 16p13.3      Physical location : 96.978 - 103.632
Synonym name RNA polymerase III subunit (hRPC11)
Synonym symbol(s) HRPC11, C11-RNP3, C11, RPC10, C11, HLD21, My010, RPC12.5
EC.number 2.7.7.6
DNA
TYPE functioning gene
STRUCTURE 7.20 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1372 - 108 - 1998 9869639
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine    
 stomach    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one ribbon-type zinc finger
mono polymer complex
HOMOLOGY
intraspecies homolog to TCEA1
Homologene
FAMILY archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
CATEGORY RNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
basic FUNCTION
  • required for proper pausing and termination during transcription
  • synthesizing transfer and small ribosomal RNAs
  • encodes the RPC11 subunit of Pol III, which has been implicated in the processes of transcription termination and reinitiation
  • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component a small essential subunit of RNA polymerase III
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TCEA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS