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FLASH GENE
Symbol IFT140 contributors: mct - updated : 22-12-2020
HGNC name intraflagellar transport 140 homolog (Chlamydomonas)
HGNC id 29077
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine TPR repeats
  • five WD repeats
    • HOMOLOGY
    interspecies homolog to murine Ift140 (81.4pc)
    Homologene
    FAMILY
    CATEGORY immunity/defense , motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • regulates retrograde protein transport in ciliated cells
  • pivotal role of IFT140 in proper development and function of ciliated cells
  • IFT140 is required for development and maintenance of outer segments of photoreceptors
  • both IFT43 and IFT140 are involved in mobilizing ciliary precursors from the cytoplasmic pool during flagellar regeneration
  • cilia gene IFT140 is likely essential in promoting dentin formation and reparation
  • likely not only plays a role in sperm flagella assembling, but is also involved in critical assembly of proteins that interface between the germ cell plasma and the Sertoli cell
  • IFT140 may play an important role in the process of chondrogenic and osteogenic differentiation during bone development
  • IFT140-positive cells mainly contribute to the early stage of bone formation
  • is a core component of the intraflagellar transport-complex A, responsible for retrograde ciliary trafficking and ciliary entry of membrane proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IFT-A protein complex consists of IFT43, WDR35, IFT122, TTC21B, IFT140 and WDR19 and is associated with THM1 and TULP3
  • subunit of IFT complex A, which is specialized for retrograde transportation in cilia
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RRPAS , RP80 , PKDL1
    Susceptibility to infertility
    Variant & Polymorphism other
  • IFT140 variants that cause infertility
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • expression level was downregulated in the long bones of murine osteoporosis models