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FLASH GENE

Symbol

IFT140

contributors: mct - updated : 22-12-2020

HGNC name	intraflagellar transport 140 homolog (Chlamydomonas)
HGNC id	29077

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014714 31 - 5277 - 1462 - 2019 31034313

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid         Nervous brain       highly Homo sapiens Reproductive female system ovary     highly   male system testis     highly Mus musculus Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol Digestive odontoblast Homo sapiens Fetal

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nine TPR repeats
	five WD repeats

HOMOLOGY

interspecies

homolog to murine Ift140 (81.4pc)

Homologene

FAMILY

CATEGORY

immunity/defense , motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome

basic FUNCTION	regulates retrograde protein transport in ciliated cells
	pivotal role of IFT140 in proper development and function of ciliated cells
	IFT140 is required for development and maintenance of outer segments of photoreceptors
	both IFT43 and IFT140 are involved in mobilizing ciliary precursors from the cytoplasmic pool during flagellar regeneration
	cilia gene IFT140 is likely essential in promoting dentin formation and reparation
	likely not only plays a role in sperm flagella assembling, but is also involved in critical assembly of proteins that interface between the germ cell plasma and the Sertoli cell
	IFT140 may play an important role in the process of chondrogenic and osteogenic differentiation during bone development
	IFT140-positive cells mainly contribute to the early stage of bone formation
	is a core component of the intraflagellar transport-complex A, responsible for retrograde ciliary trafficking and ciliary entry of membrane proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	IFT-A protein complex consists of IFT43, WDR35, IFT122, TTC21B, IFT140 and WDR19 and is associated with THM1 and TULP3
	subunit of IFT complex A, which is specialized for retrograde transportation in cilia

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RRPAS , RP80 , PKDL1

Susceptibility

to infertility

Variant & Polymorphism other	IFT140 variants that cause infertility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

expression level was downregulated in the long bones of murine osteoporosis models