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FLASH GENE

Symbol

TMEM204

contributors: npt/mct - updated : 23-08-2010

HGNC name	transmembrane protein 204
HGNC id	14158

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	26.89 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024600 3 - 943 24 226 - Kearsey (2004)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine         Lymphoid/Immune thymus       predominantly Nervous brain

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a potential N-glycosylation site
	four alpha-helical transmembrane domains
	a C-terminal PDZ domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	novel regulator of KDR and FLT4 signaling pathways and of normal lymphatic vessel structure (Saharinen 2010)
	modulator of KDR and FLT4 signals required for lymphatic vascular development (Saharinen 2010)
	has an essential function in the lymphatic vasculature (Saharinen 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with vascular endothelial growth factor receptor-2 KDR and FLT4 and attenuates the transcription factor CREB phosphorylation via these receptors (Saharinen 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS