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FLASH GENE
Symbol PTX4 contributors: SGE/npt - updated : 13-07-2010
HGNC name pentraxin 4, long
HGNC id 14171
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunespleen    
 thymus    
Nervousbrain   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one pentaxin domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • pentraxin (PTX) superfamily
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • may be part of the humoral arm of innate immunity and behave as functional ancestor of antibodies by mediating agglutination, complement activation and opsonization (Martinez de la Torre 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding two Ca2+ ions per subunit
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS