basic FUNCTION
| functions in the post-translational attainment of enzyme activity for both lipoprotein lipase and hepatic lipase (Doolittle 2009) |
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involved in the maturation of lipoprotein lipase (LPL) and hepatic lipase in endoplasmic reticulum (Cefalu 2009) |
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is believed to act as a client specific chaperone for dimeric lipases |
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is a chaperone localized to the endoplasmic reticulum (ER) and required for the post-translational maturation and activation of several vascular lipases |
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is an unfolded protein response target gene, and ATF6 signaling is sufficient and necessary for activation of the LMF1 promoter |
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LMF1 has a broader role than simply folding lipases, and we identified fibronectin and the low-density lipoprotein receptor (LDLR) as novel LMF1 clients that contain multiple, non-sequential disulfide bonds |
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is needed for secretion of some ER client proteins that require reduction of non-native disulfides during their folding |
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is a protein essential for the maturation of lipoprotein lipase (LPL) |