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FLASH GENE

Symbol

WDR24

contributors: mct - updated : 28-06-2017

HGNC name	WD repeat domain 24
HGNC id	20852

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.70 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032259 9 - 3165 NP_115635 - 790 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

WD repeat domain

HOMOLOGY

Homologene

FAMILY

WD repeat WDR24 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION

promotes lysosome acidification and autophagic flux in mammalian cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	WDR24 has both CRTC1 dependent and independent functions in the regulation of cellular metabolism
	is a key effector of the GATOR2 complex, required for both CRTC1 activation and the CRTC1 independent regulation of lysosomes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS