Symbol
| GNB1
| contributors: mct/npt - updated : 01-06-2016
|
HGNC name
| guanine nucleotide binding protein (G protein), beta polypeptide 1
|
HGNC id
| 4396
|
corresponding disease(s)
|
MRD42
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| loss of function
|
GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling | |
Variant & Polymorphism
|
| |
Candidate gene
| GNB1 is a good candidate for playing a causal role in 1p36.33 deletion syndrome |
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | reproductive | breast | |
can potentially be targeted in the treatment of breast cancer |
| | |
| Gbeta1(-/-) embryos developed neural tube defects (NTDs) and abnormal actin organization was observed in the basal side of neuroepithelium, and also microencephaly and died within 2 days after birth |