Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GNB1 contributors: mct/npt - updated : 01-06-2016
HGNC name guanine nucleotide binding protein (G protein), beta polypeptide 1
HGNC id 4396
ASSOCIATED DISORDERS
corresponding disease(s) MRD42
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling
Susceptibility
Variant & Polymorphism
Candidate gene
  • GNB1 is a good candidate for playing a causal role in 1p36.33 deletion syndrome
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    can potentially be targeted in the treatment of breast cancer
    ANIMAL & CELL MODELS
  • Gbeta1(-/-) embryos developed neural tube defects (NTDs) and abnormal actin organization was observed in the basal side of neuroepithelium, and also microencephaly and died within 2 days after birth