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FLASH GENE

Symbol

MS4A8B

contributors: - updated : 24-02-2004

HGNC name	membrane-spanning 4-domains, subfamily A, member 8B
HGNC id	13380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12.1      Physical location : 60.467.046 - 60.483.282
Synonym symbol(s)	MS4A4

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	16.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage
cell lines	B cells lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

transmembrane (TM) protein comprising a short intracellular domain,four transmembrane segments (4TM) and a long cytoplasmic tail,involved in intracellular signaling

HOMOLOGY

interspecies	homolog to murine Ms4a8b
	homolog to murine Ms4a2

Homologene

FAMILY

membrane-spanning 4-domains,subfamily A

CATEGORY

signaling , receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

involved in the regulation of B cell activation and proliferation

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

component of oligomeric cell surface complex involved in signal transduction

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS