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FLASH GENE

Symbol

GJB4

contributors: mct/npt - updated : 17-09-2009

HGNC name	gap junction protein, beta 4, 30.3kDa
HGNC id	4286

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.15 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153212 1 - 1243 NP_694944 - 266 - van Steesel (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	N teminus cytoplasmic loop
	two extracellular domain
	four transmembrane domains
	C terminus cytoplasmic

HOMOLOGY

Homologene

FAMILY	Gap junction channel family
	connexin family
	beta-type (group I) subfamily

CATEGORY

regulatory , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to membrane

basic FUNCTION	functional partners in the formation of keratinocyte cap junctions
	regulation of epidermal differentiation and maintenance of epidermal homeostasis

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EKV , PSEK2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS