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FLASH GENE

Symbol

ZAK

contributors: mct/npt - updated : 02-03-2016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	leucine zipper (LZ) motif
	sterile alpha motif (SAM)
	a kinase catalytic domain

mono polymer

homomer , dimer , polymer

HOMOLOGY

Homologene

FAMILY

MAPKKK family

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	disrupting actin stress fibers and shrinkage of cells
	mitogen-activated protein kinase kinase kinase (MAP3K) that activates the stress-activated protein kinase/c-jun N-terminal kinase pathway and activates NF-kappaB
	contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway
	decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP1 transcription factor
	MAPK14 and JNK pathways function downstream of ZAK during chondrogenesis
	is a novel key regulator of chondrogenesis

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	mitogen activated protein kinase kinase kinase leading to MAPK cascade

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	actin filaments
	activating ERK, JNK/SAPK, p38 and ERK5 pathways
	plays an essential role in the onset of chondrogenesis through triggering the induction of SOX6 expression by SOX9

cell & other

REGULATION

activated by

osmotic shock

ASSOCIATED DISORDERS

corresponding disease(s)

CNM6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lung cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression

ANIMAL & CELL MODELS