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FLASH GENE

Symbol

ZAK

contributors: mct/npt - updated : 02-03-2016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CNM6 centronuclear myopathy-6
Location	2q31.3      Physical location : 173.940.564 - 174.132.736
Genatlas name	sterile-alpha motif and leucine zipper containing kinase AZK
Synonym name	MLK-like mitogen-activated protein triple kinase
	mixed lineage kinase with a leucine zipper and a sterile alpha motif
	cervical cancer suppressor gene 4 protein
	MLK-related kinase
Synonym symbol(s)	MLTK, MAPKKK, mlklak, MLK7, AZK, MLT, MRK, HCCS-4, AZKMLK7, pk
EC.number	2.7.11.25

DNA

TYPE	functioning gene
STRUCTURE	192.17 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016653 20 splicing 3867 NP_057737 - 800 - 2001 11042189 MLTK alpha C terminal sterile motif NM_133646 12 - 7194 NP_598407 51.3 455 - 2001 11042189 MLTK beta C terminal region homolog to TAK1

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Reproductive male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	leucine zipper (LZ) motif
	sterile alpha motif (SAM)
	a kinase catalytic domain

mono polymer

homomer , dimer , polymer

HOMOLOGY

Homologene

FAMILY

MAPKKK family

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	disrupting actin stress fibers and shrinkage of cells
	mitogen-activated protein kinase kinase kinase (MAP3K) that activates the stress-activated protein kinase/c-jun N-terminal kinase pathway and activates NF-kappaB
	contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway
	decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP1 transcription factor
	MAPK14 and JNK pathways function downstream of ZAK during chondrogenesis
	is a novel key regulator of chondrogenesis

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	mitogen activated protein kinase kinase kinase leading to MAPK cascade

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	actin filaments
	activating ERK, JNK/SAPK, p38 and ERK5 pathways
	plays an essential role in the onset of chondrogenesis through triggering the induction of SOX6 expression by SOX9

cell & other

REGULATION

activated by

osmotic shock

ASSOCIATED DISORDERS

corresponding disease(s)

CNM6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lung cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression

ANIMAL & CELL MODELS