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FLASH GENE
Symbol ZAK contributors: mct/npt - updated : 02-03-2015
Location 2q31.1      Physical location : 173.940.564 - 174.132.736
Genatlas name sterile-alpha motif and leucine zipper containing kinase AZK
Synonym name
  • MLK-like mitogen-activated protein triple kinase
  • mixed lineage kinase with a leucine zipper and a sterile alpha motif
  • cervical cancer suppressor gene 4 protein
  • MLK-related kinase
  • Synonym symbol(s) MLTK, MAPKKK, mlklak, MLK7, AZK, MLT, MRK, HCCS-4, AZKMLK7, pk
    EC.number 2.7.11.25
    DNA
    TYPE functioning gene
    STRUCTURE 192.17 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ13096 2q31.1 hypothetical protein FLJ13096 MRPS29P2 2q31.2 mitochondrial ribosomal protein S29 pseudogene 2 LOC389060 2 similar to ribosomal protein S15 CYBRD1 2q31 cytochrome b reductase 1 LOC391460 2 similar to 60S ribosomal protein L21 DNCI2 2q24-q31 dynein, cytoplasmic, intermediate polypeptide 2 SLC25A12 2q24-q31 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 HAT1 2q31.2-q33.1 histone acetyltransferase 1 MAP1D 2q31.1 methionine aminopeptidase 1D DLX1 2q32 distal-less homeo box 1 DLX2 2q32 distal-less homeo box 2 ITGA6 2q22-q31 integrin, alpha 6 PDK1 2q31.1 pyruvate dehydrogenase kinase, isoenzyme 1 CGEF2 2q31 pyruvate dehydrogenase kinase, isoenzyme 1 ZAK 2q24.2 pyruvate dehydrogenase kinase, isoenzyme 1 LOC391461 2 similar to ribosomal protein S2; 40S ribosomal protein S2 CDCA7 2q31 cell division cycle associated 7 LOC344178 2q31.1 similar to peptidylprolyl isomerase A (cyclophilin A) LOC344181 2q31.1 similar to ribosomal protein L5; 60S ribosomal protein L5 SP3 2q31 Sp3 transcription factor LOC389061 2 LOC389061 LOC389062 2 LOC389062 LOC391462 2 similar to protein 40kD PTD004 2q31.1 hypothetical protein PTD004 LOC391463 2 similar to Leucine-rich repeat-containing protein 2 LOC389063 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389064 2 hypothetical gene supported by AK128215 CIR 2q31.1 CBF1 interacting corepressor SES3 2q31.1 secernin 3 GPR155 2q31.1 G protein-coupled receptor 155 WASPIP 2q31.1 Wiskott-Aldrich syndrome protein interacting protein LOC151561 2q31.2 similar to H3 histone, family 3B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 3867 - 800 - 2001 11042189
  • MLTK alpha
  • C terminal sterile motif
  • 12 - 7194 51.3 455 - 2001 11042189
  • MLTK beta
  • C terminal region homolog to TAK1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • leucine zipper (LZ) motif
  • sterile alpha motif (SAM)
  • a kinase catalytic domain
  • mono polymer homomer , dimer , polymer
    HOMOLOGY
    Homologene
    FAMILY
  • MAPKKK family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • disrupting actin stress fibers and shrinkage of cells
  • mitogen-activated protein kinase kinase kinase (MAP3K) that activates the stress-activated protein kinase/c-jun N-terminal kinase pathway and activates NF-kappaB
  • contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway
  • decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP1 transcription factor
  • MAPK14 and JNK pathways function downstream of ZAK during chondrogenesis
  • is a novel key regulator of chondrogenesis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text mitogen activated protein kinase kinase kinase leading to MAPK cascade
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin filaments
  • activating ERK, JNK/SAPK, p38 and ERK5 pathways
  • plays an essential role in the onset of chondrogenesis through triggering the induction of SOX6 expression by SOX9
  • cell & other
    REGULATION
    activated by osmotic shock
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression
    ANIMAL & CELL MODELS