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FLASH GENE
Symbol RANBP17 contributors: mct - updated : 22-05-2012
HGNC name RAN binding protein 17
HGNC id 14428
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal GTP binding protein motif
  • a CRM1 homology region
    • HOMOLOGY
    interspecies ortholog to C.elegans C35A5.8
    intraspecies paralog to RANBP16
    Homologene
    FAMILY importin beta superfamily of nuclear transport receptors
    CATEGORY receptor nuclear , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,pore
    text binding the nuclear pore complexes
    basic FUNCTION
  • preventing activation of RanGTPase by RanGAP
  • XPO7 and RANBP17 are novel regulators of TCF3 protein action
  • involved in the nucleocytoplasmic transport, and may have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and also in the intramanchette transport during spermiogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binding to a nucleoporin implicated in translocation of transport receptors
  • specific interaction of TCF3 isoform E12 with RANBP17, a novel member of the importin-beta superfamily (this interaction maps to the CRM1 homology region of RANBP17)
  • is one of the interacting partners of sperm maturation 1 (SPEM1) (potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    t(5;14)(q33-34;q11) translocation constitutes a recurrent rearrangement in acute lymphoblastic leukemia, with fusion of RANBP17 and TCRD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS