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FLASH GENE

Symbol

RANBP17

contributors: mct - updated : 22-05-2012

HGNC name	RAN binding protein 17
HGNC id	14428

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal GTP binding protein motif
	a CRM1 homology region

HOMOLOGY

interspecies

ortholog to C.elegans C35A5.8

intraspecies

paralog to RANBP16

Homologene

FAMILY

importin beta superfamily of nuclear transport receptors

CATEGORY

receptor nuclear , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nuclear envelope,pore
text	binding the nuclear pore complexes

basic FUNCTION	preventing activation of RanGTPase by RanGAP
	XPO7 and RANBP17 are novel regulators of TCF3 protein action
	involved in the nucleocytoplasmic transport, and may have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and also in the intramanchette transport during spermiogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	directly binding to a nucleoporin implicated in translocation of transport receptors
	specific interaction of TCF3 isoform E12 with RANBP17, a novel member of the importin-beta superfamily (this interaction maps to the CRM1 homology region of RANBP17)
	is one of the interacting partners of sperm maturation 1 (SPEM1) (potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     t(5;14)(q33-34;q11) translocation constitutes a recurrent rearrangement in acute lymphoblastic leukemia, with fusion of RANBP17 and TCRD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS