Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RANBP17 contributors: mct - updated : 22-05-2012
HGNC name RAN binding protein 17
HGNC id 14428
RNA
TRANSCRIPTS type messenger
text several transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 4576 - 1088 - 2000 11024021
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal GTP binding protein motif
  • a CRM1 homology region
  • HOMOLOGY
    interspecies ortholog to C.elegans C35A5.8
    intraspecies paralog to RANBP16
    Homologene
    FAMILY importin beta superfamily of nuclear transport receptors
    CATEGORY receptor nuclear , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,pore
    text binding the nuclear pore complexes
    basic FUNCTION
  • preventing activation of RanGTPase by RanGAP
  • XPO7 and RANBP17 are novel regulators of TCF3 protein action
  • involved in the nucleocytoplasmic transport, and may have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and also in the intramanchette transport during spermiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binding to a nucleoporin implicated in translocation of transport receptors
  • specific interaction of TCF3 isoform E12 with RANBP17, a novel member of the importin-beta superfamily (this interaction maps to the CRM1 homology region of RANBP17)
  • is one of the interacting partners of sperm maturation 1 (SPEM1) (potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    t(5;14)(q33-34;q11) translocation constitutes a recurrent rearrangement in acute lymphoblastic leukemia, with fusion of RANBP17 and TCRD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS