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FLASH GENE

Symbol

CYP2D6

contributors: mct/npt - updated : 01-07-2008

HGNC name	cytochrome P450, family 2, subfamily D, polypeptide 6
HGNC id	2625

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CYP2D6DM

related resource

Human Cytochrome P450 (CYP) Allele Nomenclature Committee

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function reduced CYP2D6 activity was a negative risk factor for methamphetamine dependence (Otani 2008)

Susceptibility

to poor metabolizer phenotype (debrisoquine, sparteine) to acute lymphoid and myeloid leukemia

Variant & Polymorphism other	certain alleles result in the poor metabolizer phenotype
	"null" variants increasing the risk of acute lymphoid and myeloid leukemia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS