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FLASH GENE
Symbol NOL3 contributors: mct - updated : 29/10/2008
HGNC name nucleolar protein 3 (apoptosis repressor with CARD domain)
HGNC id 7869
Location 16q22.1      Physical location : 67.204.404 - 67.209.643
Synonym name
  • nucleolar protein of 30 kDa
  • apoptosis repressor with CARD
  • muscle-enriched cytoplasmic protein
  • Synonym symbol(s) NOP30, ARC, NOP, MYC, MYP, NOP30, CARD2, FLJ35304
    DNA
    TYPE functioning gene
    STRUCTURE 5.24 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 1496 30 219 . nuclear . heart, skeletal muscle 1999 10196175
  • also called NOP30
  • may be involved in RNA splicing
  • oligomer
  • binding to SFRS9/SRp30C
  • also interacting with NPM1
  • negatively regulating p53
  • 6 splicing 1885 22.5 208 cytoplasmic 1999 10196175
  • also called MYP
  • may inhibit apoptosis
  • binding to CASP2/caspase-2 and CASP8/caspase-8
  • inhibiting caspase-8 activity
  • 4 - 1515 - 208 - -
    also called variant 2 or MYP
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
    Digestivesalivary gland   highly
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal predominantly Homo sapiens
    Muscularstriatumcardiac predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal caspase recruitment domain (CARD)
  • a C terminal region rich in proline and glutamic acid
  • mono polymer polymer
    HOMOLOGY
    interspecies homolog to rattus Nol3 (85.4 pc)
    homolog to murine Nol3 (85.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in alternative splice site selection
  • inhibiting caspase 2 and 8
  • being a Ca(2+)-dependent regulator of caspase 8 and cell death
  • inhibitor of apoptosis in that it antagonizes both the extrinsic (death receptor) and intrinsic (mitochondrial/ER) apoptosis pathways
  • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text regulation of apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • Ca2+
  • protein
  • alternating apoptosis induced by TRADD, FADD
  • binding to the RS domain of SFRS9 (Srp30c)
  • interacting with TFPT
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the epithelium of primary breast cancers compared with benign breast tissue and to confer chemo- and radiation-resistance
    tumoral     --over  
    in most colon cancer cell lines and in almost all primary colon cancers compared with corresponding controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker marker of human colon cancer
    Therapy target
    ANIMAL & CELL MODELS