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FLASH GENE
Symbol GOLGA4 contributors: mct/npt - updated : 03-03-2018
HGNC name golgi autoantigen, golgin subfamily a, 4
HGNC id 4427
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil structure stabilized by heptad repeats, granin motif
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GLD), that associate with the trans-Golgi network (TGN) via a GRIP domain, and GRIP domains of GOLGA4 and GOLGA1 bind discriminately to distinct membrane subdomains of the TGN
    • HOMOLOGY
    Homologene
    FAMILY
  • golgin subfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text
  • trans Golgi
  • GOLGA1, GOLGA4 are targeted to the Golgi membrane through their GRIP domains
  • ARFRP1 and GOLGA4 were detected in the same compartment close to the nucleus, presumably the trans-Golgi
    • basic FUNCTION
  • Golgi complex antigen targeted by autoantibodies associated with Sjogren syndrome
  • GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
  • functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements
  • key regulator of TNF secretion and LPS activation of macrophages results in increased Golgi carriers for export
  • coiled-coil protein that recycles between the cytosol and buds/vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6x
  • interacting with ARL1
  • CD99 also binds GOLGA4 9)
  • controls the recruitment of proteins such as GOLGA4 to the trans-Golgi
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RAF1 in melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS