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FLASH GENE

Symbol

GOLGA4

contributors: mct/npt - updated : 03-03-2018

HGNC name	golgi autoantigen, golgin subfamily a, 4
HGNC id	4427

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       mouth tongue     highly   stomach       highly Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	coiled-coil structure stabilized by heptad repeats, granin motif
	a RAB6 interaction domain
	a C terminal Golgi localization domain (GLD), that associate with the trans-Golgi network (TGN) via a GRIP domain, and GRIP domains of GOLGA4 and GOLGA1 bind discriminately to distinct membrane subdomains of the TGN

HOMOLOGY

Homologene

FAMILY

golgin subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleoplasm
text	trans Golgi
	GOLGA1, GOLGA4 are targeted to the Golgi membrane through their GRIP domains
	ARFRP1 and GOLGA4 were detected in the same compartment close to the nucleus, presumably the trans-Golgi

basic FUNCTION	Golgi complex antigen targeted by autoantibodies associated with Sjogren syndrome
	GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
	functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements
	key regulator of TNF secretion and LPS activation of macrophages results in increased Golgi carriers for export
	coiled-coil protein that recycles between the cytosol and buds/vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RAB6x
	interacting with ARL1
	CD99 also binds GOLGA4 9)
	controls the recruitment of proteins such as GOLGA4 to the trans-Golgi

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with RAF1 in melanomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS