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FLASH GENE
Symbol GOLGA4 contributors: mct/npt - updated : 03-03-2015
HGNC name golgi autoantigen, golgin subfamily a, 4
HGNC id 4427
Location 3p22.2      Physical location : 37.284.681 - 37.408.370
Synonym name
  • golgin 245
  • trans-Golgi p230
  • peripheral membrane protein p230, brefeldin A-sensitive, identified using anti Golgi autoantibodies from a patient with Sjogren syndrome
  • Synonym symbol(s) GCP2, GCP2, GOLG, MU-RMS-40.18, p230, TGP230, golgin-240, CRPF46
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 123.59 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    STAC 3p22.3 src homology three (SH3) and cysteine rich domain LOC205655 3p22.1 similar to hypothetical protein MGC8902 KIAA1765 3p22.1 KIAA1765 protein KIAA0342 3p24.2-p23 KIAA1765 protein LOC389106 3 LOC389106 LOC389107 3 similar to Hsp70/Hsp90 organizing protein homolog CG2720-PA LOC389108 3 LOC389108 LOC391527 3 similar to chromosome 2 open reading frame 7 EPM2AIP1 3p22.1 EPM2A (laforin) interacting protein 1 MLH1 3p21.3 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) LRRFIP2 3p24.3-p23 leucine rich repeat (in FLII) interacting protein 2 FLJ31715 3p22.1 hypothetical protein FLJ31715 GOLGA4 3p22-p21.3 golgi autoantigen, golgin subfamily a, 4 APRG1 3p22.1 AP20 region protein ITGA9 3p21.3 integrin, alpha 9 CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88) OSR1 3p22-p21.3 oxidative-stress responsive 1 SLC22A13 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 13 SLC22A14 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 14 XYLB 3p22-p21.3 xylulokinase homolog (H. influenzae)
    RNA
    TRANSCRIPTS type messenger
    text 14 alternative transcripts encoding altogether 12 proteins
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 7886 - 2230 - 2008 18394601
    - - - 60 - - 2008 18394601
  • highly homologous to a 527 amino acid sequence of the C-terminal portion of the protein Golgin-245
  • localized exclusively to the centrosome during interphase, although it dispersed throughout the cytoplasm at the onset of mitosis
  • centrosome-related protein that associates with the centrosome in a cell cycle-dependent manner and is involved in the progression of the cell cycle and M phase mechanism
  • 23 - 7868 - 2243 - 2008 18394601
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     mouthtongue  highly
     stomach   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • coiled-coil structure stabilized by heptad repeats, granin motif
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GLD), that associate with the trans-Golgi network (TGN) via a GRIP domain, and GRIP domains of GOLGA4 and GOLGA1 bind discriminately to distinct membrane subdomains of the TGN
  • HOMOLOGY
    Homologene
    FAMILY
  • golgin subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text
  • trans Golgi
  • GOLGA1, GOLGA4 are targeted to the Golgi membrane through their GRIP domains
  • ARFRP1 and GOLGA4 were detected in the same compartment close to the nucleus, presumably the trans-Golgi
  • basic FUNCTION
  • Golgi complex antigen targeted by autoantibodies associated with Sjogren syndrome
  • GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
  • functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements
  • key regulator of TNF secretion and LPS activation of macrophages results in increased Golgi carriers for export
  • coiled-coil protein that recycles between the cytosol and buds/vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6x
  • interacting with ARL1
  • CD99 also binds GOLGA4 9)
  • controls the recruitment of proteins such as GOLGA4 to the trans-Golgi
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS