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FLASH GENE
Symbol GOLGA2 contributors: mct/npt/pgu - updated : 18-05-2015
HGNC name golgi autoantigen, golgin subfamily a, 2
HGNC id 4425
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two predicted zinc fingers at its N-terminus, binding to the golgin p115, which may contribute to the tethering of Golgi membranes before membrane fusion
  • rich in coiled-coil structures
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GLD) called the GRID domain (anchored to the membrane through binding of its C-terminus to the Golgi reassembly and stacking protein of 65 kDa, GRASP65)
    • HOMOLOGY
    interspecies ortholog to rattus cis Golgi matrix protein Gm130
    Homologene
    FAMILY
  • golgin subfamily
    • CATEGORY antigen , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • cis-golgi matrix protein
  • localized to the cytoplasmic face of cis-Golgi membranes
  • peripheral membrane protein strongly attached to the Golgi membrane
  • cis-golgi matrix protein, overlapping with VPS13B, a peripheral Golgi membrane protein
    • basic FUNCTION
  • processing and transporting proteins through the Golgi apparatus
  • mitotic Golgi phosphoprotein, implicated in the stacking of Golgi cisternae, which can be thought of as tethering without subsequent membrane fusion, and in regulation of centrosome function
  • involved in membrane tethering at the endoplasmic reticulum (ER) to Golgi intermediate compartment and cis-Golgi
  • role in the regulation of centrosome morphology, position and function during interphase
  • important players in the nucleation of microtubules at the Golgi apparatus
  • with GOLGB1, and GORASP1, facilitates vesicle fusion to the Golgi membrane as a vesicle "tethering factor"
  • is also involved in the maintenance of the Golgi structure and plays a major role in the disassembly and reassembly of the Golgi apparatus during mitosis
  • potentially involved in the control of glycosylation, cell cycle progression, and higher order cell functions such as cell polarization and directed cell migration
  • redundant, Ser25 phosphorylation of GOLGA2 is an independent pathway that ensure Golgi vesiculation and mitotic progression
  • its functions are modulated by heparan sulfate (HS) glycosaminoglycans and therefore possibly controlled by extracellular cues
  • implicated in ciliogenesis through control of dynein-2 localization
  • role of TRIP11 in several trafficking steps at the ER-Golgi interface, some of which are partially redundant with GOLGA2
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • Golgi complex antigen targeted to autoantibodies associated with Sjögren syndrome
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6x proteins
  • vesicle docking protein VDP /p115
  • binding to STX5 is specific, direct, and mediated by the membrane-proximal region of GOLGA2
  • interactions of GOLGA2 with STX5 and RAB1A are also regulated by mitotic phosphorylation, which is likely to contribute to the inhibition of ER to Golgi trafficking that occurs when mammalian cells enter mitosis
  • interacting with USO1
  • interacting with AKAP9 (recruitment of AKAP9 on the Golgi membranes through GOLGA2 allows centrosome-associated nucleating activity to extend to the Golgi, to control the assembly of subsets of microtubules ensuring specific functions within the Golgi or for transporting specific cargos to the cell periphery)
  • binding to the A-kinase anchoring protein AKAP9 participates in the regulation of microtubule nucleation on cis-Golgi membranes
  • suppression of GOLGA2 results in mis-localization of WDR34, the intermediate chain of dynein-2
  • GOLGA2 directly interacts with WAC, and this interaction is required for autophagy
  • WAC and GOLGA2 interact with the ATG8 homolog GABARAP and regulate its subcellular localization
  • PIK3R4 interaction with the golgin GOLGA2
  • at the Golgi, PIK3R4 and GOLGA2 form a protein complex devoid of PIK3C3 to ensure the IFT20-dependent sorting and transport of membrane proteins from the cis-Golgi to the primary cilium
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS