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FLASH GENE
Symbol LYPLA3 contributors: - updated : 23-01-2004
HGNC name lysophospholipase 3 (lysosomal phospholipase A2)
HGNC id 17163
Location 16q22.1      Physical location : -
Genatlas name
Synonym name
  • LCAT-like lysophospholipase
  • 1-O-acylceramide synthase
  • lysosomal phospholipase A2
  • lysophospholipase 3
  • Synonym symbol(s) LLPL, ACS, LPLA2, DKFZp564A0122
    EC.number 3.1.1.5, 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Endocrinepancreas    
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide cleavage site
  • one lipase motif (AXSXG)
  • several N-linked glycosylation sites
  • HOMOLOGY
    interspecies ortholog to rattus lypla3 (86 pc)
    intraspecies homolog to LCAT
    Homologene
    FAMILY
  • AB hydrolase superfamily
  • Lipase family
  • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • hydrolysing lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    catabolism phospholipids
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding HTL
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS