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FLASH GENE

Symbol

SLC2A4

contributors: mct - updated : 22-06-2018

HGNC name	solute carrier family 2 (facilitated glucose transporter), member 4
HGNC id	11009

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in adipose tissue but preserved in muscle in insuline-resitant states such as obesity and type 2 diabetes

Susceptibility

non insulin dependent diabetes mellitus (type 2)

Variant & Polymorphism	polymorphic variant

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   promising target for pharmacogenomics of insulin resistance cancer     therapeutic strategy entailing selective SLC2A4, SLC2A11, SLC2A8 inhibition to specifically target aberrant glucose metabolism in cancer

ANIMAL & CELL MODELS

G4A -/- mice